Integrating Wearable Devices and Recommendation System: Towards a Next Generation Healthcare Service Delivery

Researchers have identified lifestyle diseases as a major threat to human civilization. These diseases gradually progress without giving any warning and result in a sudden health aggravation that leads to a medical emergency. As such, individuals can only avoid the life-threatening condition if they regularly monitor their health status. Health recommendation systems allow users to continuously monitor their health and deliver proper health advice to them. Also, continuous health monitoring depends on the real-time data exchange between health solution providers and users. In this regard, healthcare providers have begun to use wearable devices and recommendation systems to collect data in real time and to manage health conditions based on the generated data. However, we lack literature that has examined how individuals use wearable devices, what type of data the devices collect, and how providers use the data for delivering solutions to users. Thus, we decided to explore the available literature in this domain to understand how wearable devices can provide solutions to consumers. We also extended our focus to cover current health service delivery frameworks with the help of recommender systems. Thus, this study reviews health-monitoring services by conglomerating both wearable device and recommendation system to come up with personalized health and fitness solutions. Additionally, the paper elucidates key components of an advanced-level real-time monitoring service framework to guide future research and practice in this domain

Elucidation of Macroeconomic Determinants for Prognosis of Buruli Ulcer

This paper discusses the macroeconomic factors, which are responsible for the spread of Buruli Ulcer. As the definitive indicators for the transmission of this neglected tropical disease have not been found yet, therefore, the indicators being found by means of this study can provide significant insights to the health policy makers. This study is carried out for ten African countries and Papua New Guinea for the duration of 2002–2013. Fixed effect panel regression has been employed for the study on the orthogonally transformed dataset. We find that the health policy initiatives have been found to have little or no impact on the Buruli Ulcer prevalence. We also find that access to water from improved sources can reduce the probability of the incidence of this disease

Impact of high-performance work practices on efficiency and effectiveness of multispecialty healthcare service delivery in an emerging economy – role of relational coordination

Healthcare institutions have been working to improve the efficiency and effectiveness of the service delivered. The literature has argued that their capabilities have a direct effect on service outcomes. Research has explained how their capabilities can be enhanced by implementing high-performance work practices (HPWP) bundles and how these bundles can impact performance through relational coordination. However, this previous research has focused primarily on single-specialty healthcare institutions in a developed country. Inherent characteristics of multispecialty healthcare institutions (e.g., inability to standardize) and emerging economy context (e.g., absence of case manager role) motivate further investigation in this setting. Therefore, in our research, we study the impact of HPWP on the overall performance, efficiency, and effectiveness of healthcare service delivered and how this linkage is moderated by relational coordination. We analyzed 605 valid responses from different healthcare institutions located in the southern Tamil Nadu state of India using structural equation modeling. In alignment with past research, our results show that HPWP improves the overall performance and effectiveness and this linkage is moderated by relational coordination. However, HPWP's impact on efficiency and its moderation by relational coordination is insignificant. We explain the results by anchoring them to the characteristics of the multispecialty and emerging economy context

Elucidation of Macroeconomic Determinants for Prognosis of Buruli Ulcer

This paper discusses the macroeconomic factors, which are responsible for the spread of Buruli Ulcer. As the definitive indicators for the transmission of this neglected tropical disease have not been found yet, therefore, the indicators being found by means of this study can provide significant insights to the health policy makers. This study is carried out for ten African countries and Papua New Guinea for the duration of 2002–2013. Fixed effect panel regression has been employed for the study on the orthogonally transformed dataset. We find that the health policy initiatives have been found to have little or no impact on the Buruli Ulcer prevalence. We also find that access to water from improved sources can reduce the probability of the incidence of this disease

Modeling the Closed and Open State Conformations of the GABA_A Ion Channel - Plausible Structural Insights for Channel Gating

Recent disclosure of high resolution crystal structures of <i>Gloeobacter violaceus</i> (GLIC) in open state and <i>Erwinia chrysanthemii</i> (ELIC) in closed state provides newer avenues to advance our knowledge and understanding of the physiologically and pharmacologically important ionotropic GABA_A ion channel. The present modeling study envisions understanding the complex molecular transitions involved in ionic conductance, which were not evident in earlier disclosed homology models. In particular, emphasis was put on understanding the structural basis of gating, gating transition from the closed to the open state on an atomic scale. Homology modeling of two different physiological states of GABA_A was carried out using their respective templates. The ability of induced fit docking in breaking the critical inter residue salt bridge (Glu155β₂ and Arg207β₂) upon endogenous GABA docking reflects the perceived side chain rearrangements that occur at the orthosteric site and consolidate the quality of the model. Biophysical calculations like electrostatic mapping, pore radius calculation, ion solvation profile, and normal-mode analysis (NMA) were undertaken to address pertinent questions like the following: How the change in state of the ion channel alters the electrostatic environment across the lumen; How accessible is the Cl^– ion in the open state and closed state; What structural changes regulate channel gating. A “Twist to Turn” global motion evinced at the quaternary level accompanied by tilting and rotation of the M2 helices along the membrane normal rationalizes the structural transition involved in gating. This perceived global motion hints toward a conserved gating mechanism among pLGIC. To paraphrase, this modeling study proves to be a reliable framework for understanding the structure function relationship of the hitherto unresolved GABA_A ion channel. The modeled structures presented herein not only reveal the structurally distinct conformational states of the GABA_A ion channel but also explain the biophysical difference between the respective states

Modeling the Closed and Open State Conformations of the GABA_A Ion Channel - Plausible Structural Insights for Channel Gating

Recent disclosure of high resolution crystal structures of <i>Gloeobacter violaceus</i> (GLIC) in open state and <i>Erwinia chrysanthemii</i> (ELIC) in closed state provides newer avenues to advance our knowledge and understanding of the physiologically and pharmacologically important ionotropic GABA_A ion channel. The present modeling study envisions understanding the complex molecular transitions involved in ionic conductance, which were not evident in earlier disclosed homology models. In particular, emphasis was put on understanding the structural basis of gating, gating transition from the closed to the open state on an atomic scale. Homology modeling of two different physiological states of GABA_A was carried out using their respective templates. The ability of induced fit docking in breaking the critical inter residue salt bridge (Glu155β₂ and Arg207β₂) upon endogenous GABA docking reflects the perceived side chain rearrangements that occur at the orthosteric site and consolidate the quality of the model. Biophysical calculations like electrostatic mapping, pore radius calculation, ion solvation profile, and normal-mode analysis (NMA) were undertaken to address pertinent questions like the following: How the change in state of the ion channel alters the electrostatic environment across the lumen; How accessible is the Cl^– ion in the open state and closed state; What structural changes regulate channel gating. A “Twist to Turn” global motion evinced at the quaternary level accompanied by tilting and rotation of the M2 helices along the membrane normal rationalizes the structural transition involved in gating. This perceived global motion hints toward a conserved gating mechanism among pLGIC. To paraphrase, this modeling study proves to be a reliable framework for understanding the structure function relationship of the hitherto unresolved GABA_A ion channel. The modeled structures presented herein not only reveal the structurally distinct conformational states of the GABA_A ion channel but also explain the biophysical difference between the respective states

Modeling the Closed and Open State Conformations of the GABA_A Ion Channel - Plausible Structural Insights for Channel Gating

Recent disclosure of high resolution crystal structures of <i>Gloeobacter violaceus</i> (GLIC) in open state and <i>Erwinia chrysanthemii</i> (ELIC) in closed state provides newer avenues to advance our knowledge and understanding of the physiologically and pharmacologically important ionotropic GABA_A ion channel. The present modeling study envisions understanding the complex molecular transitions involved in ionic conductance, which were not evident in earlier disclosed homology models. In particular, emphasis was put on understanding the structural basis of gating, gating transition from the closed to the open state on an atomic scale. Homology modeling of two different physiological states of GABA_A was carried out using their respective templates. The ability of induced fit docking in breaking the critical inter residue salt bridge (Glu155β₂ and Arg207β₂) upon endogenous GABA docking reflects the perceived side chain rearrangements that occur at the orthosteric site and consolidate the quality of the model. Biophysical calculations like electrostatic mapping, pore radius calculation, ion solvation profile, and normal-mode analysis (NMA) were undertaken to address pertinent questions like the following: How the change in state of the ion channel alters the electrostatic environment across the lumen; How accessible is the Cl^– ion in the open state and closed state; What structural changes regulate channel gating. A “Twist to Turn” global motion evinced at the quaternary level accompanied by tilting and rotation of the M2 helices along the membrane normal rationalizes the structural transition involved in gating. This perceived global motion hints toward a conserved gating mechanism among pLGIC. To paraphrase, this modeling study proves to be a reliable framework for understanding the structure function relationship of the hitherto unresolved GABA_A ion channel. The modeled structures presented herein not only reveal the structurally distinct conformational states of the GABA_A ion channel but also explain the biophysical difference between the respective states

Modeling the Closed and Open State Conformations of the GABAA Ion Channel - Plausible Structural Insights for Channel Gating

Recent disclosure of high resolution crystal structures of Gloeobacter violaceus (GLIC) in open state and Erwinia chrysanthemii (ELIC) in closed state provides newer avenues to advance our knowledge and understanding of the physiologically and pharmacologically important ionotropic GABAA ion channel. The present modeling study envisions understanding the complex molecular transitions involved in ionic conductance, which were not evident in earlier disclosed homology models. In particular, emphasis was put on understanding the structural basis of gating, gating transition from the closed to the open state on an atomic scale. Homology modeling of two different physiological states of GABAA was carried out using their respective templates. The ability of induced fit docking in breaking the critical inter residue salt bridge (Glu155β2 and Arg207β2) upon endogenous GABA docking reflects the perceived side chain rearrangements that occur at the orthosteric site and consolidate the quality of the model. Biophysical calculations like electrostatic mapping, pore radius calculation, ion solvation profile, and normal-mode analysis (NMA) were undertaken to address pertinent questions like the following: How the change in state of the ion channel alters the electrostatic environment across the lumen; How accessible is the Cl− ion in the open state and closed state; What structural changes regulate channel gating. A “Twist to Turn” global motion evinced at the quaternary level accompanied by tilting and rotation of the M2 helices along the membrane normal rationalizes the structural transition involved in gating. This perceived global motion hints toward a conserved gating mechanism among pLGIC. To paraphrase, this modeling study proves to be a reliable framework for understanding the structure function relationship of the hitherto unresolved GABAA ion channel. The modeled structures presented herein not only reveal the structurally distinct conformational states of the GABAA ion channel but also explain the biophysical difference between the respective state